Midstream Health is taking a bit of a different approach to healthcare AI by focusing on reducing hospitals’ costs rather than boosting their revenue. The startup uses AI to identify savings opportunities across fragmented spending data, which helps health systems like Mount Sinai and CommonSpirit quickly improve their purchasing decisions.

The post Why Some Hospitals Are Betting on Midstream Health to Help Eliminate Waste appeared first on MedCity News.

Innovaccer is committing $250 million to expand its AI agent platform, which automates workflows across areas like prior authorization, revenue cycle management and population health. The move comes amid an ongoing debate over whether administrative AI tools can ultimately reduce costs for providers.

The post Why Innovaccer Is Pouring $250M into Its Agentic AI Platform appeared first on MedCity News.

HeartFlow, which makes AI tools to analyze cardiac images, sued its rival Cleerly, alleging infringement on six patents. Cleerly is pushing back.

The post Heartflow Sues Cardiac AI Rival Cleerly Over Alleged IP Theft appeared first on MedCity News.

Luminai raised $38 million in Series B funding to scale its AI platform that automates healthcare administrative workflows. The company is working with Cleveland Clinic to expand the use of its system across high-volume processes, starting with referral management.

The post Luminai Raises $38M With Cleveland Clinic Using Its AI for Hospital Operations appeared first on MedCity News.

Mass General Brigham evaluates AI tools by carefully monitoring real-world performance before scaling them system-wide. At HIMSS earlier this month, Rebecca Mishuris, the health system’s chief health information officer and vice president of digital, explained what this process looks like.

The post How Mass General Brigham Decides Which AI Tools Are Worth Scaling appeared first on MedCity News.

Michael Meucci, CEO of health data platform Arcadia, thinks health systems are changing their thinking about ROI when it comes to AI projects. As providers face tighter budgets, he said they’re broadening how they measure AI’s ROI, including benefits like reducing clinician burnout.

The post How Are Health Systems Assessing ROI for AI Tools? appeared first on MedCity News.

Fawad Butt, CEO of Penguin Ai, gave his candid thoughts on where the healthcare AI market is headed, including how data leakage could be fueling smarter AI models and the limits of agentic AI in enterprise settings.

The post Why Agentic AI Is Useful But Limited & Other Hot Takes on the AI Market appeared first on MedCity News.

At Wayne General Hospital in rural Mississippi, clinicians are using Eko Health’s AI-powered digital stethoscope to detect heart conditions earlier in patients with limited access to specialists.

The post How A Small Rural Hospital Is Using AI to Catch Heart Disease Sooner appeared first on MedCity News.

Utah is piloting an AI system developed by Doctronic to autonomously handle routine prescription refills, aiming to reduce delays and boost medication adherence. But a report from Mindgard AI claiming that there are vulnerabilities in the company’s chatbot underscores the broader challenge regulators and developers face in ensuring healthcare AI systems remain safe and reliable in real-world use.

The post The Saga of Utah’s Rx Refill Bot: A Bold Bet on AI & Researchers Who Cried Foul appeared first on MedCity News.

Katie Jacobs Stanton, founder of Moxxie Ventures, shared some details of how she and her team evaluate healthcare AI startups. She stressed the need for founders with deep industry expertise, differentiated products and realistic distribution strategies.

The post Inside One VC’s Litmus Test for Investable Healthcare AI Startups appeared first on MedCity News.

Epic has unveiled its new “agent factory,” a platform that lets health systems build AI agents that are capable of orchestrating entire workflows across the EHR.

The post Epic Is Letting Health Systems Build Their Own Agents — But Are They Ready? appeared first on MedCity News.

Waiv, formerly the diagnostics division of AI biotech Owkin, developed AI-enabled testing technologies that found use in clinical settings and in cancer drug research. Spinning out as an independent company enables Waiv to pursue its own growth strategy, co-founder and CEO Meriem Sefta said.

The post Startup Waiv Spins Out of Owkin With $33M to Bring AI Precision to Cancer Decisions appeared first on MedCity News.

Flagship Pioneering-founded Generate Biomedicines aims to offer less frequent injections compared to a blockbuster asthma drug from partners Amgen and AstraZeneca. Generate’s drug comes from a “programable biology” platform technology that uses AI and machine learning to design proteins with desirable properties.

The post Generate Biomedicines’ IPO Brings In $400M for Pivotal Tests of Severe Asthma Drug appeared first on MedCity News.

OpenAI announced a new dedicated platform for health conversations. The company said the new offering is not intended for medical diagnosis or treatment — but rather to provide support for personal health navigation.

The post OpenAI Launches ChatGPT Health: 5 Things to Know appeared first on MedCity News.

New research shows that while health systems are pouring money into AI tools, most are still struggling to use the technology to meaningfully engage patients. Moving beyond generic outreach to “N-of-1 personalization” could be key to closing engagement gaps and improving patient outcomes at scale, said Amy Bucher, chief behavioral officer at Lirio.

The post Why AI Is Falling Short on Patient Engagement at Hospitals appeared first on MedCity News.

Clinical decision support startup Aidoc has become a major player in healthcare AI thanks to its focus on acute, life-or-death cases and its R&D-first approach. As Aidoc continues to innovate, Chief Business Officer Tom Valent thinks its commitment to patient safety and transparency will be key contributors to future success.

The post Why Are Aidoc’s AI Tools Winning Over Radiologists? appeared first on MedCity News.

Dr. Prajnan Das, department chair of Gastrointestinal (GI) Radiation Oncology at MD Anderson Cancer Center, talks about how precision medicine has evolved and how AI may actually be the technology that supercharges the conversion of the knowledge about human biology to personalized treatments that work.

The post How Precision Medicine and AI are Evolving: An MD Anderson Perspective appeared first on MedCity News.

Mass General Brigham spun out a new company offering a generative AI platform that can rapidly interpret both structured and unstructured clinical data. Right now, the tool’s primary application is to accelerate and improve the accuracy of patient screening for clinical trials.

The post Mass General Brigham Spins Out Generative AI Startup appeared first on MedCity News.

Nvidia has quietly become one of the most influential players in healthcare technology by supplying the accelerated computing and AI infrastructure that powers everything from imaging to drug discovery. The company’s restraint — focusing on enabling the ecosystem rather than owning it — has helped cement its role as the indispensable backbone of the healthcare industry’s AI transformation.

The post This Year’s Hottest Healthcare Company Isn’t Even a Healthcare Company appeared first on MedCity News.

Philips showcased two major imaging innovations at RSNA 2025 — one a CT system that integrates AI into its hardware, and the other a new helium-free MRI model that embeds AI directly into signal acquisition. Both aim to improve image quality, efficiency and ease of integration — but commercial availability and real-world adoption are still forthcoming.

The post What Is Philips Showing Off at RSNA This Year? appeared first on MedCity News.

Samsung launched a new ultrasound system at this year’s RSNA conference. The system, called the R20, is designed to reduce user variability through real-time guidance, as well as provide AI-powered diagnostic support.

The post Samsung’s New Ultrasound System Wants to Make Every Scan Consistent appeared first on MedCity News.

Ostro’s health AI literacy course set a Guinness World Record this week, with 698 participants completing the 30-minute online lesson in 24 hours. The course offers practical training on generative AI, compliance and human-in-the-loop processes to improve understanding across the healthcare and life sciences industries.

The post Ostro Breaks a World Record in Its Bid to Better Health AI Literacy appeared first on MedCity News.

Sanford Health is embedding AI into its EHR to turn vast patient data into actionable insights. Tools like a chronic kidney disease module and a personalized colon cancer screening model are helping clinicians catch disease earlier and tailor care to individual patients, explained Jeremy Cauwels, the health system’s chief medical officer.

The post How Sanford Health Embeds AI into Its EHR to Catch Disease Earlier & Personalize Care appeared first on MedCity News.

Iambic’s latest financing follows the presentation of data for its breast cancer drug during the recent European Society of Medical Oncology conference. Our financing roundup includes capital raised by startups developing novel therapies immunology, metabolic disorders, genetic diseases, and more.

The post Startup Iambic Raises $100M for Clinical Trials of AI-Discovered Cancer Drugs appeared first on MedCity News.

Startups in the ambient documentation space are moving beyond simple scribing to tools that can handle tasks like intake, coding and care coordination, according to Heidi Health CEO Tom Kelly. Standing out in this crowded market is a challenge, and companies’ success will hinge on creating products clinicians actually want to use, he added.

The post How One CEO Thinks Ambient Scribes Can Differentiate Themselves appeared first on MedCity News.

Flagship Pioneering’s newest startup is Expedition Medicines, a company whose artificial intelligence-driven technology platform analyzes the human proteome to learn the chemistry of binding small molecules to protein targets long considered “undruggable.” Expedition already has a cancer drug R&D alliance with Pfizer.

The post Startup Expedition Medicines Launches to Learn Nature’s Rules for Binding Elusive Proteins appeared first on MedCity News.

Pfizer Ventures led the Series B financing of Cartography Biosciences, whose lead program addresses a promising target for colorectal cancer. The startup’s drugs come from platform technologies that analyze data from healthy cells and cancer cells to identify cancer-specific targets.

The post Cartography Bio Corrals $67M to Bring Targeted Colorectal Cancer Drug Into the Clinic appeared first on MedCity News.

In a crowded healthcare AI market, the winners will be those that control key leverage points — where data is created, workflows are streamlined and value is delivered across stakeholders. This will differentiate winning AI startups from incumbents and copycat competitors, said Morgan Cheatham, head of healthcare and life sciences at Breyer Capital.

The post Positioning & Distribution Will Determine the Winning Healthcare AI Startups, Investor Says  appeared first on MedCity News.

Chirag Shah, partner at Define Ventures, thinks the success of a healthcare AI startup often depends on its ability to move beyond a narrow point solution. By integrating AI into workflows and expanding from initial “wedges” into full platforms, startups can stand out from the competition, he said.

The post What One Investor Believes Is the Key to Healthcare AI Success appeared first on MedCity News.

At Epic’s annual Users Group Meeting, the EHR behemoth highlighted its growing AI strategy — announcing tools promising to benefit providers, payers and patients alike.

The post 3 Announcements You Don’t Want to Miss from Epic’s Annual Meeting appeared first on MedCity News.