April has seen a slew of executive hires, promotions and layoffs across the healthcare industry. For instance, Aledade, Humana and Zimmer Biomet named new executives. There were also layoffs at organizations including Baylor Scott & White Health Plan, Novo Nordisk and UnityPoint Health.

The post Healthcare Moves: A Monthly Summary of Hires, Exits and Layoffs appeared first on MedCity News.

Coultreon Biopharma’s lead drug candidate, acquired from Galapagos, is a small molecule designed to selectively inhibit a novel immunology target called SIK3. The Series A financing will support Phase 2 clinical trials in psoriasis and ulcerative colitis.

The post Immunology-Focused Coultreon Adds $125M for Pills That Pack the Punch of Injectable Biologics appeared first on MedCity News.

Nvidia and Hoppr are betting that healthcare AI will scale not through standalone applications, but through a new infrastructure layer that lets providers develop and deploy their own imaging models.

The post Why Healthcare AI Still Can’t Scale — and How Nvidia & Hoppr Are Trying to Fix It appeared first on MedCity News.

Midstream Health is taking a bit of a different approach to healthcare AI by focusing on reducing hospitals’ costs rather than boosting their revenue. The startup uses AI to identify savings opportunities across fragmented spending data, which helps health systems like Mount Sinai and CommonSpirit quickly improve their purchasing decisions.

The post Why Some Hospitals Are Betting on Midstream Health to Help Eliminate Waste appeared first on MedCity News.

Kurma Partners’ new fund is the venture capital firm’s fourth and largest. Previous Kurma investments have led to exits that include the acquisitions of Corlieve Therapeutics, Emergence Therapeutics, and Amolyt Pharma.

The post VC Firm Kurma Partners Closes €215M Fund in Pursuit of ‘Disruptive Therapeutic Solutions’ appeared first on MedCity News.

Telehealth clinic Hone Health partnered with imaging company BodySpec to give its patients access to DEXA body composition scans. The partnership seeks to help providers and patients on GLP-1s distinguish fat loss from muscle loss and better evaluate how these drugs are affecting the body.

The post Beyond the Scale: How Imaging Can Help Determine GLP-1 Efficacy appeared first on MedCity News.

The AI Health Fund launched Treehub, a new residency program designed to back and build healthcare AI startups at the earliest stages, often before companies are even formed. It is supported by prominent figures in the Silicon Valley venture capital world, including Tim Draper and Anne Wojcicki.

The post Top Silicon Valley VCs Are Backing a New Health Tech Residency Program appeared first on MedCity News.

Tortugas Neurosciences’ two lead programs are in-licensed oral small molecules in development for schizophrenia and tinnitus. The startup is led by veterans of Sage Therapeutics, a neuroscience biotech that was acquired last year.

The post Neuro Startup Tortugas Unveils $106M and a Pipeline of Drugs for the Brain appeared first on MedCity News.

Kelonia Therapeutics brings to Eli Lilly an in vivo cell therapy in early clinical development for multiple myeloma. The deal complements Lilly’s acquisitions of Verve Therapeutics and Orna Therapeutics in the past year, each taking different approaches to developing in vivo genetic medicines.

The post Eli Lilly Makes Another In Vivo Genetic Medicines Move With $3.2B Kelonia Acquisition appeared first on MedCity News.

CMS is rolling out its health tech ecosystem initiative with a new Medicare app library that functions like a healthcare “App Store,” aiming to make patient data more portable and accessible across vetted digital health apps.

The post CMS’ New ‘App Store’ Is Trying to Turn Interoperability Into a Digital Health Distribution System appeared first on MedCity News.

The fatty liver disease MASH is one of the metabolic disorders that Nula Therapeutics is pursuing. The startup’s small molecules are intended to restore the integrity of the nuclear envelope, a cellular membrane whose dysfunction can contribute to metabolic disease.

The post Startup Nula Emerges to Advance a New Class of Medicines for Metabolic Disease appeared first on MedCity News.

Innovaccer is committing $250 million to expand its AI agent platform, which automates workflows across areas like prior authorization, revenue cycle management and population health. The move comes amid an ongoing debate over whether administrative AI tools can ultimately reduce costs for providers.

The post Why Innovaccer Is Pouring $250M into Its Agentic AI Platform appeared first on MedCity News.

Eli Lilly is paying up to $300 million for CrossBridge Bio, a startup developing antibody drug conjugates that deliver two drug payloads to cancers. Beyond potentially better efficacy, CrossBio’s dual approach could also fight drug resistance.

The post Eli Lilly Buys Startup CrossBridge Bio to Bring a More Powerful Strike to Tumors appeared first on MedCity News.

HeartFlow, which makes AI tools to analyze cardiac images, sued its rival Cleerly, alleging infringement on six patents. Cleerly is pushing back.

The post Heartflow Sues Cardiac AI Rival Cleerly Over Alleged IP Theft appeared first on MedCity News.

Luminai raised $38 million in Series B funding to scale its AI platform that automates healthcare administrative workflows. The company is working with Cleveland Clinic to expand the use of its system across high-volume processes, starting with referral management.

The post Luminai Raises $38M With Cleveland Clinic Using Its AI for Hospital Operations appeared first on MedCity News.

Gilead Sciences’ Tubulis acquisition brings antibody drug conjugates in clinical development for cancer. Analysts say the Tubulis platform technologies that yielded these ADCs could also help Gilead develop drugs in other therapeutic areas.

The post Gilead’s Pipeline Strategy Takes Shape With $3B Acquisition of Cancer Biotech Tubulis appeared first on MedCity News.

Digital health funding rebounded in the first quarter of 2026, reaching $4 billion across 110 deals, according to data from Rock Health. The surge was fueled mainly by megadeals, reflecting a market where investors are placing larger bets on fewer startups.

The post Digital Health Startups Raised $4B in Q1: How Cash Is Flowing Amid Uncertainty appeared first on MedCity News.

Startup Pinnacle Medicines is developing peptide drugs with the same efficacy as biologic medicines and the dosing convenience of oral small molecules. The lead program of OrbiMed-incubated Pinnacle is on track to enter the clinic in asthma and chronic obstructive pulmonary disease.

The post Pinnacle Medicines Adds $89M for Oral Peptides With Properties of Injectable Biologics appeared first on MedCity News.

Uma (Veerappan) Nuggehalli of Flare Capital Partners thinks the healthcare AI startups that will come out on top will be companies that integrate seamlessly into workflows, build proprietary datasets and quickly determine how to sell their technology.

The post What Will Separate Healthcare AI Winners From Losers? appeared first on MedCity News.

Untreated dental problems are driving millions of Americans to emergency rooms each year, costing the country billions and worsening chronic health conditions. Experts say bridging the historic divide between medical and dental care — through data connectivity, integrated health centers and AI-driven tools — could improve patient outcomes and reduce healthcare spending.

The post From Cavities to Chronic Disease: Why Medicine and Dentistry Can’t Operate Separately appeared first on MedCity News.

March has seen a slew of executive hires, exits and layoffs across the healthcare industry. For instance, Flare Capital Partners, SCAN Group and Advocate Health named new executives. There were also layoffs at organizations including Oracle, Takeda and Blue Shield of California.

The post Healthcare Moves: A Monthly Summary of Hires, Exits and Layoffs appeared first on MedCity News.

Michael Meucci, CEO of health data platform Arcadia, thinks health systems are changing their thinking about ROI when it comes to AI projects. As providers face tighter budgets, he said they’re broadening how they measure AI’s ROI, including benefits like reducing clinician burnout.

The post How Are Health Systems Assessing ROI for AI Tools? appeared first on MedCity News.

Fawad Butt, CEO of Penguin Ai, gave his candid thoughts on where the healthcare AI market is headed, including how data leakage could be fueling smarter AI models and the limits of agentic AI in enterprise settings.

The post Why Agentic AI Is Useful But Limited & Other Hot Takes on the AI Market appeared first on MedCity News.

Adonis raised a $40 million Series C funding round to help hospitals use AI to tackle denied and underpaid claims. Its platform automates manual revenue cycle tasks and provides real-time insights, which allows staff to focus on higher-value work. Customers include Mount Sinai Health System, Baptist Health South Florida, AdventHealth and ApolloMD.

The post Adonis Scores $40M for AI Platform Aiming to Boost Hospital Revenue appeared first on MedCity News.

At Wayne General Hospital in rural Mississippi, clinicians are using Eko Health’s AI-powered digital stethoscope to detect heart conditions earlier in patients with limited access to specialists.

The post How A Small Rural Hospital Is Using AI to Catch Heart Disease Sooner appeared first on MedCity News.

Rachel Springate, general partner at Muse Capital, said the next wave of healthcare startups will be driven by consumer demand — but pure direct-to-consumer models rarely work. Companies like Midi Health, Mavida Health and Mahmee are showing a different path: starting with patients, collecting outcomes data, and integrating with clinicians, payers and the broader healthcare system.

The post Why Pure DTC Doesn’t Work in Healthcare, Per Muse Capital appeared first on MedCity News.

Utah is piloting an AI system developed by Doctronic to autonomously handle routine prescription refills, aiming to reduce delays and boost medication adherence. But a report from Mindgard AI claiming that there are vulnerabilities in the company’s chatbot underscores the broader challenge regulators and developers face in ensuring healthcare AI systems remain safe and reliable in real-world use.

The post The Saga of Utah’s Rx Refill Bot: A Bold Bet on AI & Researchers Who Cried Foul appeared first on MedCity News.

Katie Jacobs Stanton, founder of Moxxie Ventures, shared some details of how she and her team evaluate healthcare AI startups. She stressed the need for founders with deep industry expertise, differentiated products and realistic distribution strategies.

The post Inside One VC’s Litmus Test for Investable Healthcare AI Startups appeared first on MedCity News.

Turquoise Health raised $40 million in a Series C round to expand beyond price transparency into managing healthcare contracts. The startup’s platform aims to simplify payer–provider agreements, reduce administrative waste and enable patients to see guaranteed upfront prices.

The post Turquoise Health Snags $40M to Simplify Healthcare Contracts & Payments appeared first on MedCity News.

GuardDog Telehealth admitted it misrepresented its services to access patients’ health information, marking the first major concession in Epic’s lawsuit against Health Gorilla and other defendants accused of exploiting interoperability networks. The broader case is still ongoing.

The post Why The Epic-Health Gorilla Case Just Got Juicier appeared first on MedCity News.